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This is not simply about getting peptides into your nose
& Moeller-Bertram, T
The researchers reported that psilocybin treatment in both groups produced large decreases in depression, and that depression severity remained low one, three, six, and 12 months after treatment
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Tiberi and Caron (1994) J.Biol.Chem
The peptides were transported from the surface of the olfactory bulb or bottom region of the brain around the hypothalamus to the deeper part of the brain through the CSF or perivascular spaces of the cerebral artery ( Intranasal coadministration of noncovalently bound L-penetratin with insulin increased insulin levels in the brain and its pharmacological effects were tested at two differential stages of memory impairment using a senescence-accelerated mouse-prone 8 (SAMP8) model that exhibits spontaneous aging and senescence ( The investigators suggested that the phenomenon might occur due to the competition between insulin and A for the degradative pathway by insulin-degrading enzyme (IDE), an enzyme involved in the clearance of extracellular A from the brain (Shiiki et al., 2004)
